Publications majeures

• Impact of TNF-α (−308G˃A and −857C˃T) promoter variants on susceptibility to chronic hepatitis B virus
  infection in a cohort of Mauritanian patients: Pilot study Saffiya Mounira ENNAHOUI; Abdallah SID
  M’HAMED, Fatimetou VETEN, Sidi M. Cheikh Bouna; Abdelhamid BARAKAT; Tetou SOUMBARA and Ahmed
  HOUMEIDA (under press in BMC Microilogy 2026)
• Genetics of prelingual isolated deafness and Usher syndrome in the Maghreb and Jordan: Harnessing the
  potential of homozygosity.
  Riahi Z, Boucher S, Abdi S, Wong Jun Tai F, Singh-Estivalet A, Aghaie A, Niasme-Grare M, Hardelin JP,
  Behlouli A, Dahmani M, Talbi S, Bouyacoub Y, Mkaouar R, Charfeddine C, Amalou G, Bakhchane A, Bousfiha
  A, Salime S, Elrharchi S, Salame M, Hadrami M, Boussaty E, Charoute H, Detsouli M, Snoussi K, Rouba H,
  Hachmi HE, Veten F, Meiloud G, Marrakchi J, Zainine R, Chahed H, Besbes G, Trabelsi M, Mrad R, Kraoua I,
  Ouhab S, Djennaoui D, Boudjenah F, Chouery E, Mustapha M, Houmeida A, Barakat A, Khodja FA, Makrelouf
  M, Zenati A, Beltaief N, Abdelhak S, Petit C, Bonnet C.Proc Natl Acad Sci U S A. 2025 Dec
  16;122(50):e2518445122. doi: 10.1073/pnas.2518445122. Epub 2025 Dec 8.
• Prevalence and genetic etiology of poly-cystic ovarian syndrome (PCOS) in Mauritania.
  Marieme Elwafi  1 ,  Abdi Ahmed   , Omar Akhouayri, Ahmed Zein   ,  Hamma Abdelkader   ,  Roughaya Selman , Ahmed
  Houmeida . Front Reprod Health 2025 Jun 9:7:1461405. doi:10.3389/frph.2025.146140
• Splice-altering variant of PJVK gene in a Mauritanian family with non-syndromic hearing impairment Malak Salame, Crystel Bonnet, Amrit Singh-estivalet ,, Selma Mohamed brahim, Solene Roux, Ely Cheikh Boussaty, Mouna HadramI, Cheikh Tijani Hamed, Abdellahi M’HAMED SIDI, Fatimetou VETEN, Christine Petit and Ahmed Houmeida. J Appl Genet. 2024 Sep 4. doi: 10.1007/s13353-024-00903-x.
• Genetic variation of TLR3 gene is associated with the outcome of hepatitis B infection in Mauritanianpatients: case control study.Soumbara T, Bonnet C, Hamed CT, Veten F, Hemeyine M, Fall-Malick FZ, El Yezid MM, Diallo A,Mounah MM, Houmeida A. BMC Infect Dis. 2024 Jun 21;24(1):616. doi: 10.1186/s12879-024-09503-w.
• Implication Of Isolated Anti-Hbc Antibodies Among Mauritanian Blood Donors
  Tetou Soumbara, Moustapha Mouhamedou Mounah , MohamedM.ElYezi , F-ZahraFall-Malick , CheikhT.Hamed , Saffiya M. Ennahoui1 , Sidi M. Cheikh Bouna , Khadijetou Ba ,Ahmed Houmeida. Teikyo Medical journal, Volume 47, Issue 02, February, 2024 8373.
• Genomic Evidence of Multiple Introductions of SARS-CoV-2 in Mauritania.Abdelmalick Abdelmalick, Sofia Sehli,  Abdellah Idrissi Azami ,  Nihal Habib ,  Najib Al Idrissi ,  LahcenBelyamani ,Ahmed Houmeida, and Hassan Ghazal. Bioinform Biol Insights. 2023; 17:11779322231167927. Published online 2023 Apr 25. doi: 10.1177/11779322231167927
• Identification a novel pathogenic LRTOMT mutation in Mauritanian families with nonsyndromic
  deafness. Salame M, Bonnet C, Moctar ECM, Brahim SM, Dedy A, Vetah LA, Veten F, Hamed CT,
  Petit C, Houmeida A. Eur Arch Otorhinolaryngol. 2023 Mar 16. doi: 10.1007/s00405-023-07907-z.
  Online ahead of print.PMID: 36928321
  Epidemiological and clinicopathological features of breast cancer in Mauritania
  Selma Mohamed Brahim, Cheikh Tijani Hamed, Ekht Elbenina Zein, Malak Salame, Fatimetou Veten,
  Mohamed Vall Zein, Meriem Khyatti, Ahmed Houmeida, Ahmedou Tolba. Academic Journal of Health
  Sciences. 2023; 38 (1): 120-127
  Screening of BRCA1/2 variants in Mauritanian breast cancer patientsSelma Mohamed Brahim, Ekht
  Elbenina Zein, Crystel Bonnet, Cheikh Tijani Hamed, Malak Salame, Mohamed Vall Zein, Meriem
  Khyatti, Ahmedou Tolba, Ahmed Houmeida
  BMC Cancer. 2022; 22: 802. Published online 2022 Jul 20. doi: 10.1186/s12885-022-09903-8.
  General Oncology Care in Mauritania.Selma Mohamed Brahim, Ekhtelebenina Zin, Ahmed
  HOUMEIDA and Ahmedou TOLBA. DOI: 10.1007/978-981-16-7945-2 . 2022.Publisher: Springer. ISBN:
  978-981-16-7947-6
  Characteristics of Helicobacter pylori strains isolated from Mauritanian patients.
  Khiddi F, Abdellahi MVM, Horma MA, Billoet A, Collobert G, Amar AM, Nech HDM, Vadel EHM,
  Houmeida A, Raymond J, Dauga C, Gastli N.Helicobacter. 2020 Oct;25(5):e12726. doi:
  10.1111/hel.12726. Epub 2020 Jul 19.PMID: 32686319
  Mutation profile of glaucoma candidate genes in mauritanian families with primary congenital
  glaucoma
  Mouna Hadrami , Crystel Bonnet , Christina Zeitz , FatimetouVeten , Med Biya , cheikh t. Hamed ,
  christelCondroyer , Panfeng Wang , MoustaphaSaleck , SidiC, Qingjiong Zhang,Isabelle Audo,Christine
  Petit and Ahmed Houmeida Mol Vis. 2019 Jul 13;25:373-381. eCollection 2019.PMID: 31367175 
  A novel missense mutation of GJA8 causes congenital cataract in a large Mauritanian family.
  Hadrami M, Bonnet C, Veten F, Zeitz C, Condroyer C, Wang P, Biya M, Sidi Ahmed MA, Zhang Q,
  Cheikh S, Audo I, Petit C, Houmeida A.
  Eur J Ophthalmol. 2018 Oct 29:1120672118804757. doi: 10.1177/1120672118804757. [
  HLA class I (-A, -B, -C) and class II (-DR, -DQ) polymorphism in the Mauritanian population.
  Hamed CT, Meiloud G, Veten F, Hadrami M, Ghaber SM, Boussaty EC, Habti N, Houmeida A.
  BMC Med Genet. 2018 Jan 3;19(1):2. doi: 10.1186/s12881-017-0514-4.
  Mutations in CDC14A, Encoding a Protein Phosphatase Involved in Hair Cell Ciliogenesis, Cause
  Autosomal-Recessive Severe to Profound Deafness.
  Delmaghani S, Aghaie A, Bouyacoub Y, El Hachmi H, Bonnet C, Riahi Z, Chardenoux S, Perfettini I,
  Hardelin JP, Houmeida A, Herbomel P, Petit C.
  Am J Hum Genet. 2016 Jun 2;98(6):1266-1270. doi: 10.1016/j.ajhg.2016.04.015.
  Etiology and associated GJB2 mutations in Mauritanian children with non-syndromic hearing loss.
  Moctar EC, Riahi Z, El Hachmi H, Veten F, Meiloud G, Bonnet C, Abdelhak S, Errami M, Houmeida A.
  Eur Arch Otorhinolaryngol. 2016 Nov;273(11):3693-3698. Epub 2016 Apr 11.
  Occurrence of the Codon 24 (A > T) Mutation in the Mauritanian Population.
  Veten F, Ghaber S, Habti N, Houmeida A.
  Hemoglobin. 2015;39(4):296-7. doi: 10.3109/03630269.2015.1043060. Epub 2015 Jun 5.
  Study of the T16189C variant and mitochondrial lineages in Tunisian and overall Mediterranean
  region.

Hsouna S, Ben Halim N, Lasram K, Meiloud G, Arfa I, Kerkeni E, Romdhane L, Jamoussi H, Bahri S,
Ben Ammar S, Abid A, Barakat A, Houmeida A, Abdelhak S, Kefi R.
Mitochondrial DNA A DNA MappSeq Anal. 2016;27(2):1558-63. doi: 10.3109/19401736.2014.953136.
Epub 2015 Sep 4.
E23K variant in KCNJ11 gene is associated with susceptibility to type 2 diabetes in the Mauritanian
population.
Abdelhamid I, Lasram K, Meiloud G, Ben Halim N, Kefi R, Samb A, Abdelhak S, Houmeida A.
Prim Care Diabetes. 2014 Jul;8(2):171-5. doi: 10.1016/j.pcd.2013.10.006. Epub 2013 Dec 12.

Type 2 diabetes in Mauritania: prevalence of the undiagnosed diabetes, influence of family history and
maternal effect.
Meiloud G, Arfa I, Kefi R, Abdelhamid I, Veten F, Lasram K, Ben Halim N, SidiMhamed A, Samb A,
Abdelhak S, Houmeida AO.
Prim Care Diabetes. 2013 Apr;7(1):19-24. doi: 10.1016/j.pcd.2012.12.002. Epub 2013 Feb 4.
Distribution of Rhesus and Kell blood group frequencies in the Mauritanian population.
Hamed CT, Bollahi MA, Abdelhamid I, Sow A, Sidi AM, Habti N, Houmeida A.
Blood Transfus. 2013 Jan;11(1):154-5. doi: 10.2450/2012.0022-12. Epub 2012 Oct 10. No abstract
available.
Hb S [β6(A3)Glu→Val, GAG>GTG] and β-globin gene cluster haplotype distribution in Mauritania.
Veten FM, Abdelhamid IO, Meiloud GM, Ghaber SM, Salem ML, Abbes S, Houmeida AO.
Hemoglobin. 2012;36(4):311-5. doi: 10.3109/03630269.2012.688782. Epub 2012 May 24.
Frequencies and ethnic distribution of ABO and Rh(D) blood groups in Mauritania: results of first
nationwide study.
Hamed CT, Bollahi MA, Abdelhamid I, Med Mahmoud MA, Ba B, Ghaber S, Habti N, Houmeida A.
Int J Immunogenet. 2012 Apr;39(2):151-4. doi: 10.1111/j.1744-313X.2011.01064.x. Epub 2011 Nov
29.
Mechanism of regulation of native cardiac muscle thin filaments by rigor cardiac myosin-S1 and
calcium.
Houmeida A, Heeley DH, Belknap B, White HD.
J Biol Chem. 2010 Oct 22;285(43):32760-9. doi: 10.1074/jbc.M109.098228. Epub 2010 Aug 9.
Evidence for the oligomeric state of 'elastic' titin in muscle sarcomeres.
Houmeida A, Baron A, Keen J, Khan GN, Knight PJ, Stafford WF 3rd, Thirumurugan K, Thompson B,
Tskhovrebova L, Trinick J.
J Mol Biol. 2008 Dec 12;384(2):299-312. doi: 10.1016/j.jmb.2008.09.030. Epub 2008 Sep 20.
Can the passive elasticity of muscle be explained directly from the mechanics of individual titin
molecules?
Tskhovrebova L, Houmeida A, Trinick J.
J Muscle Res Cell Motil. 2005;26(6-8):285-9.
Persistence length of titin from rabbit skeletal muscles measured with scattering and microrheology
techniques.
Di Cola E, Waigh TA, Trinick J, Tskhovrebova L, Houmeida A, Pyckhout-Hintzen W, Dewhurst C.
Biophys J. 2005 Jun;88(6):4095-106. Epub 2005 Mar 25.
Stability and folding rates of domains spanning the large A-band super-repeat of titin.
Head JG, Houmeida A, Knight PJ, Clarke AR, Trinick J, Brady RL.
Biophys J. 2001 Sep;81(3):1570-9.
Studies of the interaction between titin and myosin.
Houmeida A, Holt J, Tskhovrebova L, Trinick J.

J Cell Biol. 1995 Dec;131(6 Pt 1):1471-81.
Sequences of actin implicated in the polymerization process: a simplified mathematical approach to
probe the role of these segments.
Houmeida A, Bennes R, Benyamin Y, Roustan C.
Biophys Chem. 1995 Nov;56(3):201-14.
Interaction in vitro of scallop muscle arginine kinase with filamentous actin.
Reddy SR, Houmeida A, Benyamin Y, Roustan C.
Eur J Biochem. 1992 May 15;206(1):251-7.
Localization of a vitamin-D-binding protein interaction site in the COOH-terminal sequence of actin.
Houmeida A, Hanin V, Constans J, Benyamin Y, Roustan C.
Eur J Biochem. 1992 Feb 1;203(3):499-503.
Definition of a Ca2(+)-sensitive interface in the plasma gelsolin-actin complex.
Houmeida A, Hanin V, Feinberg J, Benyamin Y, Roustan C.
Biochem J. 1991 Mar 15;274 ( Pt 3):753-7.